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Based on epidemiological evidence and experimentation on laboratory animals, the Public Health Services have established maximum contaminant levels (MCLs) allowable in drinking water. Most of these levels allow a sufficient margin of safety; however, one must remember that acceptable contaminant levels vary widely among individuals and population groups. For example, high sodium, which may be harmless for many people, can be dangerous for the elderly, hypertensives, pregnant women, and people having difficulty in excreting sodium. Specific symptoms of different contaminants are presented in more detail in later sections.